Splicing: HACking into the unfolded-protein response
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منابع مشابه
Splicing: HACking into the unfolded-protein response
Unfolded proteins in the endoplasmic reticulum of Saccharomyces cerevisiae trigger a specialized RNA splicing event that allows the subsequent translation of the Hac1p transcription factor. This splicing can be reconstituted with Ire1p, a transmembrane kinase that has a site-specific RNase activity, and tRNA ligase.
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Cells respond to the accumulation of unfolded proteins in the endoplasmic reticulum (ER) by increasing the production of ER-resident chaperones, such as BiP and protein disulfide isomerase (PDI), that expedite protein folding and assembly in the ER lumen. In organisms as diverse as yeast and humans, this is accomplished by increasing the transcription of the genes that encode these chaperones. ...
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The unfolded protein response (UPR) is an evolutionarily conserved adaptive mechanism to increase cell survival under endoplasmic reticulum (ER) stress conditions. The UPR is critical for maintaining cell homeostasis under physiological and pathological conditions. The vital functions of the UPR in development, metabolism and immunity have been demonstrated in several cell types. UPR dysfunctio...
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ژورنال
عنوان ژورنال: Current Biology
سال: 1998
ISSN: 0960-9822
DOI: 10.1016/s0960-9822(98)70986-8